Protein Allostery in Drug Discovery (Advances in Experimental Medicine and Biology #1163) (Hardcover)

Protein Allostery in Drug Discovery (Advances in Experimental Medicine and Biology #1163) By Jian Zhang (Editor), Ruth Nussinov (Editor) Cover Image

Protein Allostery in Drug Discovery (Advances in Experimental Medicine and Biology #1163) (Hardcover)

By Jian Zhang (Editor), Ruth Nussinov (Editor)

$179.99


Special Order—Subject to Availability

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery--as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.


Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA
Product Details ISBN: 9789811387180
ISBN-10: 9811387184
Publisher: Springer
Publication Date: November 20th, 2019
Pages: 384
Language: English
Series: Advances in Experimental Medicine and Biology